Preprints

Data-driven Workflow for the Development and Discovery of N-oxyl Hydrogen Atom Transfer Catalysts

Cheng Yang, Thérèse Wild, Yulia Rakova, Stephen Maldonado, Matthew S. Sigman, and Corey R. J. Stephenson. ChemRxiv DOI:

Maximizing Driving Force in the Design of N-oxyl Hydrogen Atom Transfer Catalysts

Cheng Yang, Luke Farmer, Olaya Bernardo, Sahil Arora, Subrata Ghosh, Stephen Maldonado, Derek Pratt, Corey Stephenson. ChemRxiv DOI: 10.26434/chemrxiv-2024-ww74d

A modular photoredox route towards sulfoximines

Mark Glossbrenner, Sergio Gonzalez-Granda, Onkar Nayal, Efrey Noten, Cole Balintfy, Derek Pratt, and Corey R. J. Stephenson ChemRxiv DOI: 10.26434/chemrxiv-2023-gw0xb

A formal (3+2) cycloaddition strategy toward 2-azanorbornanes

Anthony R. Allen, Annika E. Tharp, and Corey R. J. Stephenson. ChemRxiv DOI: 10.26434/chemrxiv-2022-42h36

2024

134) Comparative techno-economic and life cycle assessment of electrocatalytic processes for lignin valorization

Zahra Ebrahimpourboura, Manish Mosalpuri, Cheng Yang, Aditya Ponukumati, Corey Stephenson, Marcus Foston, and Mark Mba Wright. Green Chem. 2024, DOI: 10.1039/D4GC01963F.

133) Bicyclo[2.1.1]hexanes via Intramolecular Formal (3+2)-Cycloaddition

Alexander S. Harmata, Elene Tatunashvili, Abigail Chang, Tao Wang, and Corey R. J. Stephenson. Angew. Chem. Int. Ed. 2024, DOI: 10.1002/anie.202413695.

132) Catalytic Olefin Transpositions Facilitated by Ruthenium N,N,N-Pincer Complexes

Alex M. Davies, Kara H. Greene, Anthony R. Allen, Nathaniel K. Szymczak, and Corey R. J. Stephenson. J. Org. Chem. 2024, 89, 9647. Initially disclosed on ChemRxiv.

131) Ethanol Upgrading with N,N,N-Pincer-Based Ru Catalysts: Delineating Key Factors Governing Catalyst Evolution and Stability

Benjamin M. Farris, Alex M. Davies, Corey R. J. Stephenson, and Nathaniel K. Szymczak. ACS Catal. 2024, 12, 8456. Initially disclosed on ChemRxiv.

130) Revisiting the Reactivity of the Dismissed Hydrogen Atom Transfer Catalyst Succinimide-N-oxyl

Cheng Yang, Luke Farmer, Derek A. Pratt, Stephen Maldonado, and Corey R. J. Stephenson. J. Am. Chem. Soc. 2024, 146, 12511. Initially disclosed on ChemRxiv.

129) Attenuating N-oxyl Decomposition for Improved Hydrogen Atom Transfer Catalysts

Cheng Yang, Luke Farmer, Elvis McFee, Rahul K. Jha, Stephen Maldonado, Derek A. Pratt, and Corey R. J. Stephenson. Angew. Chem. Int. Ed. 2024, e202315917. Initially disclosed on ChemRxiv.

128) A general alkene aminoarylation enabled by N-centered radical reactivity of sulfinamides

Efrey A. Noten, Cody H. Ng, Robert M. Wolesensky, and Corey R. J. Stephenson. Nat. Chem. 2024, 16, 599. Initially disclosed on ChemRxiv.

2023

127) Exploring Cuneanes as Potential Benzene Isosteres and Energetic Materials: Scope and Mechanistic Investigations into Regioselective Rearrangements from Cubanes

Jeong-Yu Son, Santeri Aikonen, Nathan Morgan, Alexander S. Harmata, Jesse J. Sabatini, Rosario C. Sausa, Edward F. C. Byrd, Daniel H. Ess, Robert S. Paton, and Corey R. J. Stephenson. J. Am. Chem. Soc. 2023, 145, 16355–16364. Initially disclosed on ChemRxiv.

126) Leveraging the persistent radical effect in the synthesis of trans-2,3-diaryl-dihydrobenzofurans

Bec J. Roldan, Travis A. Hammerstad, Matthew S. Galliher, Mitchell H. Keylor, Derek A. Pratt, and Corey R. J. Stephenson. Angew. Chem. Int. Ed. 2023, 62, e202305801. Initially disclosed on ChemRxiv.

125) EDA Photochemistry: Mechanistic Investigations and Future Opportunities

Alan K. Wortman, and Corey R. J. Stephenson. Chem 2023, 9, 2390-2415. DOI: 10.1016/j.chempr.2023.06.013.

124) The design of phthalimide-N-oxyl like hydrogen atom transfer catalysts

Cheng Yang, Sahil Arora, Stephen Maldonado, Derek A. Pratt, and Corey R. J. Stephenson Nat. Rev. Chem. 2023, 7, 653-666.

123) Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis

Kevin P. Cole, James J. Douglas, Travis Hammerstand, and Corey R. J. Stephenson. Org. Proc. Res. Dev. 2023, 27, 399-408.

122) TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform

Amanda L. Peiffer, Julie M. Garlick, Yujin Wu, Jesse W. Wotring, Sahil Arora, Alexander S. Harmata, Daniel A. Bochar, Corey J. Stephenson, Matthew B. Soellner, Jonathan Z. Sexton, Charles L. Brooks III, and Anna K. Mapp. ACS Med. Chem. Lett. 2023, 14, 860–866.

121) High-Throughput Optimization of Photochemical Reactions using Segmented-Flow Nanoelectrospray-Ionization Mass Spectrometry

Alexandra C. Sun, Daniel J. Steyer, Richard I. Robinson, Carol Ginsburg-Moraff, Scott Plummer, Jinhai Gao, Joseph W. Tucker, Dirk Alpers, Corey R. J. Stephenson,* and Robert T. Kennedy.* Angew. Chem. Int. Ed. 2023, e202301664; Angew. Chem. 2023, e202301664. VIP Article. Initially disclosed on ChemRxiv.

120) Formal Cycloadditions Driven by the Homolytic Opening of Strained, Saturated Ring Systems

Alexander S. Harmata, Bec J. Roldan, and Corey R. J. Stephenson. Angew. Chem. Int. Ed. 2023, 62, e202213003; Angew. Chem. 2023, 135, e202213003.

2022

119) Radical Generation Enabled by Photoinduced N–O Bond Fragmentation

Edward J. McClain, Alan K. Wortman, and Corey R. J. Stephenson. Chem. Sci. 2022, 13, 12158-12163.

118) Mechanism of Visible Light-Mediated Alkene Aminoarylation with Arylsulfonylacetamides

Anthony R. Allen, Jia-Fei Poon, Rory C. McAtee, Nicholas B. Watson, Derek A. Pratt, and Corey R. J. Stephenson. ACS Catal. 2022, 12, 8511-8526.

117) A One-Pot Photochemical Method for the Generation of Functionalized Aminocyclopentanes

James L. Collins III, Daryl Staveness, Madison J. Sowden, and Corey R. J. Stephenson. Org. Lett. 2022, 24, 4344-4348. Initially disclosed on ChemRxiv.

116) Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype

Ciria C. Hernandez, Rahilla A. Tarfa, Jose Miguel I. Limcaoco, Ruiting Liu, Pravat Mondal, Clare Hill, R. Keith Duncan, Thanos Tzounopoulos, Corey R. J. Stephenson, Matthew J. O'Meara, and Peter Wipf. Bioorg. Med. Chem. Lett. 2022, 71, 128841.

115) Valorization of Ethanol: Ruthenium-Catalyzed Guerbet and Sequential Functionalization Processes

Alex M. Davies, Zhong-Yuan Li, Corey R. J. Stephenson, and Nathaniel K. Szymczak. ACS Catal. 2022, 12, 6729-6736.

114) Catalytic Intramolecular Aminoarylation of Unactivated Alkenes with Aryl Sulfonamides

Efrey A. Noten, Rory C. McAtee, and Corey R. J. Stephenson. Chem. Sci. 2022, 13, 6942-6949. Initially disclosed on ChemRxiv.

113) Aryl Transfer Strategies Mediated by Photoinduced Electron Transfer

Anthony R. Allen, Efrey A. Noten, and Corey R. J. Stephenson. Chem. Rev. 2022, 122, 2695-2751.

2021

112) Photochemical Formal (4+2)-Cycloaddition of Imine-Substituted Bicyclo[1.1.1]pentanes and Alkenes

Alexander S. Harmata, Taylor E. Spiller, Madison J. Sowden, and Corey R. J. Stephenson. J. Am. Chem Soc. 2021, 143, 21223-21228. Initially disclosed on ChemRxiv.

111) Photochemically derived 1-aminonorbornanes provide structurally unique succinate dehydrogenase inhibitors with in vitro and in planta activity

Daryl Staveness, Mikaela Breunig, Viviana Ortiz, Hyunkyu Sang, James L. Collins III, Rory C. McAtee, Martin I. Chilvers, and Corey R. J. Stephenson. Cell Rep. Phys. Sci. 2021, 2, 100548.

110) Electrocatalytic Lignin Oxidation

Cheng Yang, Stephen Maldonado, Corey R. J. Stephenson. ACS Catal. 2021, 11, 10104-10114.

109) Mechanism of Electrochemical Generation and Decomposition of Phthalimide-N-oxyl

Cheng Yang, Luke A. Farmer, Derek A. Pratt, Stephen Maldonado, and Corey R. J. Stephenson. J. Am. Chem. Soc. 2021, 143, 10324-10332. Initially disclosed on ChemRxiv.

108) Electro-reductive Fragmentation of Oxidized Lignin Models

Cheng Yang, Gabriel Magallanes, Stephen Maldonado, and Corey R. J. Stephenson. J. Org. Chem. 2021, 86, 15927-15934.

107) Converting a Two-Week Chemistry Course for High School Students to a Virtual Format During COVID

Haley Albright, Corey R. J. Stephenson, and Corinna S. Schindler. J. Chem. Educ. 2021, 98, 2457-2464.

106) Design of a Two-Week Organic Chemistry Course for High School Students: “Catalysis, Solar Energy, and Green Chemical Synthesis"

Haley Albright, Corey R. J. Stephenson, and Corinna S. Schindler. J. Chem. Educ. 2021, 98, 2449-2456.

105) Evolution towards green radical generation in total synthesis

Matthew S. Galliher, Bec J. Roldan, and Corey R. J. Stephenson. Chem. Soc. Rev. 2021, 50, 10044-10057.

2020

104) A droplet microfluidic platform for high-throughput photochemical reaction discovery

Alexandra C. Sun, Daniel J. Steyer, Anthony R. Allen, Emory M. Payne, Robert T. Kennedy and Corey R. J. Stephenson. Nat. Commun. 2020, 11, 6202. Initially disclosed on ChemRxiv.

103) Design and Implementation of a Catalytic Electron Donor–Acceptor Complex Platform for Radical Trifluoromethylation and Alkylation

Edward J. McClain, Timothy M. Monos, Mayuko Mori, Joel W. Beatty, and Corey R. J. Stephenson. ACS Catalysis 2020, 10, 12636. Initially disclosed on ChemRxiv.

102) Organocatalytic Approach to Photochemical Lignin Fragmentation

Cheng Yang, Markus D. Kärkäs, Gabriel Magallanes, Kimberly Chan, and Corey R. J. Stephenson. Org. Lett. 2020, 22, 8082-8085.

101) Arene dearomatization through a catalytic N-centered radical cascade reaction

Rory C. McAtee, Efrey A. Noten, and Corey R. J. Stephenson. Nat. Commun. 2020, 11, 2528. Initially disclosed on ChemRxiv.

Highlighted in Synfacts by D. Trauner

100) Quinone Methide Dimers Lacking Labile Hydrogen Atoms Are Surprisingly Excellent Radical-Trapping Antioxidants

Mark A. R. Raycroft, Jean-Philippe R. Chauvin, Matthew Galliher, Kevin Romero, Corey R. J. Stephenson, and Derek A. Pratt. Chem Sci. 2020, 11, 5676-5689.

Chemical Science HOT Article

99) Synthesis of vitisin A & D enabled by a persistent radical equilibrium

Kevin J. Romero, Mitchell H. Keylor, Markus Griesser, Xu Zhu, Ethan J. Strobel, Derek A. Pratt, and Corey R. J. Stephenson. J. Am. Chem. Soc. 2020, 142, 14, 6499-6504. Initially disclosed via ChemRxiv (DOI:10.26434/chemrxiv.10294826.v1)

98) Recent Advances and Outlook for the Isosteric Replacement of Anilines

Taylor M. Sodano, Logan A. Combee, and Corey R. J. Stephenson. ACS Med. Chem. Lett. 2020, 11, 1785-1788.