RECENT PUBLICATIONS

COMPLEMENTARY APPROACHES TO ACCESS 1-AMINONORBORNANES

Our lab has developed a program investigating the 1-aminonorbornane scaffold as an aniline bioisostere. Our recent papers (here and here) describe two distinct photochemical approaches to access this scaffold.

Alkene aminoarylation with a single, bifunctional reagent is a concise synthetic strategy. We report a catalytic protocol for the addition of arylsulfonylacetamides across electron-rich alkenes with complete anti-Markovnikov regioselectivity and excellent diastereoselectivity to provide 2,2-diarylethylamines. In this process, single-electron alkene oxidation enables carbon-nitrogen bond formation to provide a key benzylic radical poised for a Smiles-Truce 1,5-aryl shift. This reaction is redox-neutral, exhibits broad functional group compatibility, and occurs at room temperature with loss of sulfur dioxide. As this process is driven by visible light, uses readily available starting materials, and demonstrates convergent synthesis, it is well suited for use in a variety of synthetic endeavors.

COMPLEMENTARY APPROACHES FOR LATE-STAGE DECARBOXYLATIVE FUNCTIONALIZATION

Our group has recently published back to back communications in Organic Letters using N-(acyloxy)pyridinium reagents as redox active species for the late-stage decarboxylative functionalization of (hetero)arenes.

 

2019 PUBLICATIONS

 

Daryl Staveness, James L. Collins III, Rory C. McAtee, and Corey R. J. Stephenson. Angew. Chem. Int. Ed. 2019in press. Initially disclosed via ChemRxiv (DOI:10.26434/chemrxiv.7390421.v1)

Related work has been included in the following patent applications:

1) Stephenson, C.R.J.; Staveness, D. U.S. Pat. Appl. No. 62/772,302, November 28, 2018.

2) Stephenson, C.R.J.; Staveness, D. U.S. Pat. Appl. No. 62/907,881, September 30, 2019. 

Scott C. Farrow, Mohamed O. Kamileen, Lorenzo Caputi, Kate Bussey, Julia E. A. Mundy, Rory C. McAtee, Corey R. J. Stephenson, and Sarah E. O’Connor. J. Am. Chem. Soc. 2019141, 12979.

Rory C. McAtee, Edward J. McClain, and Corey R. J. Stephenson. Trends in Chemistry 2019, 1, 111. 

Gabriel Magallanes, Markus D. Kärkäs, Irene Bosque, Sudarat Lee, Stephen Maldonado, and Corey R. J. Stephenson. ACS Catalysis 20199, 2252.

Alexandra C. Sun, Rory C. McAtee, Edward J. McClain, and Corey R. J. Stephenson. Synthesis 201951, 1063. 

Daryl Staveness, Taylor M. Sodano, Kangjun Li, Elizabeth A. Burnham, Klarissa D. Jackson, Corey R. J. Stephenson. Chem 20195, 215. Initially disclosed via ChemRxiv (DOI:10.26434/chemrxiv.5437255.v1)

2018 PUBLICATIONS

 

Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, ..., Corey R. J. Stephenson, ..., and Jason M. Rohde. ACS Cent. Sci. 20184, 1727.

This work included contributions from 45 academic research groups across the United States. Follow this link for a complete author list.

Daryl Staveness, James L. Collins III, Rory C. McAtee, and Corey R. J. Stephenson. ChemRxiv 2018. DOI:10.26434/chemrxiv.7390421.v1

Kevin J. Romero, Matthew S. Galliher, Mark A. R. Raycroft, Jean-Philippe R. Chauvin, Irene Bosque, Derek A. Pratt, and Corey R. J. Stephenson. Angew. Chem. Int. Ed. 201857, 17125. 

Timothy M. Monos, Rory C. McAtee, and Corey R. J. Stephenson. Science 2018361, 1369. Highlighted in Nachrichten aus der Chemie.

Kevin J. Romero, Matthew S. Galliher, Derek A. Pratt, and Corey R. J. Stephenson. Chem. Soc. Rev. 201847, 7851.

Dirk Alpers, Kevin Cole, and Corey Stephenson, Angew. Chem. Int. Ed. 201857, 12167.

85) VISIBLE LIGHT-MEDIATED DECARBOXYLATIVE ALKYLATION OF PHARMACEUTICALLY RELEVANT HETEROCYCLES

Alexandra C. Sun, Edward J. McClain, Joel W. Beatty, and Corey R. J. Stephenson. Org. Lett. 201820, 3487.

Rory C. McAtee, Joel W. Beatty, Christopher C. McAtee, and Corey R. J. Stephenson. Org. Lett. 201820, 3491.

83) LITHIUM BIS-CATECHOL BORATE AS AN EFFECTIVE REDUCTIVE QUENCHER IN PHOTOREDOX CATALYSIS

Martin J. Sevrin, Laura Furst, John D. Nguyen, James L. Collins III, and Corey R. J. Stephenson. Tetrahedron 201874, 3246.

2017 PUBLICATIONS

 

Irene Bosque, Gabriel Magallanes, Mathilde Rigoulet, Markus D. Kärkäs, and Corey R. J. Stephenson, ACS Cent. Sci. 2017, 3, 621. Highlighted in Synform.

2016 PUBLICATIONS

 

Mitchell H. Keylor, Bryan S. Matsuura, Markus Griesser, Jean-Philippe R. Chauvin, Ryan A. Harding, Mariia S. Kirillova, Xu Zhu, Oliver J. Fischer, Derek A. Pratt and Corey R. J. Stephenson, Science 2016, 354, 1260. Highlighted in C&E News.

Markus D. Kärkäs, Irene Bosque, Bryan S. Matsuura and Corey R. J. Stephenson, Org. Lett. 2016, 18, 5166.

Daryl Staveness, Irene Bosque and Corey R. J. Stephenson, Acc. Chem. Res. 2016, 49, 2295. Published as part of the special Issue on Photoredox Catalysis in Organic Chemistry.

Joel W. Beatty, James J. Douglas, Richard Miller, Rory McAtee, Kevin P. Cole and Corey R. J. Stephenson, Chem 2016, 1, 456. Highlighted in C&E News.

James J. Devery, John D. Ngyuen, Chunhui Dai and Corey R. J. Stephenson, ACS Catalysis 2016, 6, 5962.

James J. Douglas, Martin J. Sevrin and Corey R. J. Stephenson, Org. Proc. Res. Dev. 2016, 20, 1134.

James J. Douglas, Martin J. Sevrin, Kevin P. Cole and Corey R. J. Stephenson, Org. Proc. Res. Dev. 201620, 1148.

Timothy M. Monos, Alexandra C. Sun, Rory C. McAtee, James J. Devery, III and Corey R. J. Stephenson, J. Org. Chem. 201681, 6988. Selected as a Featured Article for the Special issue on Photocatalysis.

Timothy M. Monos, Gabriel Magallanes, Leanne J. Sebren and Corey R. J. Stephenson, J. Photochem. Photobiol. A 2016, 328, 240. Invited feature article.

Markus D. Kärkäs, John. A. Porco, Jr. and Corey R. J. Stephenson, Chem. Rev. 2016116, 9683. Published a part of the special issue on Photochemistry in Organic Synthesis.

Verner A. Lofstrand, Bryan S. Matsuura, Laura Furst, Jagan M. R. Narayanam and Corey R. J. Stephenson, Tetrahedron 2016, 72, 3775. Published a part of the special issue in honor of Professor Neil Garg for his receipt of the Tetrahedron Young Investigator Award.

Markus D. Kärkäs, Bryan S. Matsuura, Timothy Monos, Gabriel Magallanes and Corey R. J. Stephenson, Org. Biomol. Chem. 201614, 1853.

Elizabeth C. Swift, Theresa M. Williams and Corey R. J. Stephenson, Synlett 2016, 27, 754. Published in the special cluster of articles on modern radical chemistry.

2015 PUBLICATIONS

 

James J. Douglas, H. Albright, Martin J. Sevrin, Kevin P. Cole and Corey R. J. Stephenson, Angew. Chem. Int. Ed. 2015, 54, 14898.

Markus D. Kärkäs, Bryan S. Matsuura and Corey R. J. Stephenson, Science, 2015, 349, 1285. (Perspective Article)

Joel W. Beatty, James J. Douglas, Kevin P. Cole and Corey R. J. Stephenson, Nature Comm. 2015, 6, 7919. PMCID: PMC4533119.

Joel W. Beatty and Corey R. J. Stephenson, Acc. Chem. Res. 2015, 48, 1474. PMCID: PMC4440623. Invited contribution for the Synthesis, Design, and Molecular Function Special Issue.

James J. Devery, III and Corey R. J. Stephenson, Nature, 2015, 519, 42. (News and Views article)

Mitchell H. Keylor, Bryan S. Matsuura and Corey R. J. Stephenson, Chem. Rev. 2015, 115, 8976. PMCID: PMC4566929. Published in the Frontiers in Organic Synthesis Special Issue.

Bryan S. Matsuura, Mitchell H. Keylor, Bo Li, YuXuan Lin, Shelby Allison, Derek A. Pratt* and Corey R. J. Stephenson* Angew. Chem. Int. Ed. 2015, 54, 3754.  This article was selected as a Hot Paper by the editors of Angewandte Chemie and highlighted in Nature Chemistry and Synfacts.

James J. Devery, III, James J. Douglas, John D. Nguyen, Kevin P. Cole, Robert A. Flowers, II and Corey R. J. Stephenson, Chem. Sci. 2015, 6, 537.

2014 PUBLICATIONS

 

James J. Douglas, Kevin P. Cole, and Corey R. J. Stephenson, J. Org. Chem. 2014, 79, 11631. This paper was highlighted in OPRD and Synfacts.

Joel W. Beatty and Corey R. J. Stephenson, J. Am. Chem. Soc. 2014, 136, 10270. This paper was selected as a JACS spotlight article.

Mitchell H. Keylor, James E. Park, Carl-Johan Wallentin and Corey R. J. Stephenson, Tetrahedron 2014, 70, 4264. Special issue in honor of Tetrahedron Young Investigator Professor Sarah Reisman

James J. Douglas, John D. Nguyen, Kevin P. Cole and Corey R. J. Stephenson, Aldrichimica Acta 2014, 47, 15

Zachary J. Garlets, John D. Nguyen and Corey R. J. Stephenson, Isr. J. Chem. 2014, 54, 351. PMCID: PMC4255365. Special issue on "Flow Chemistry Concepts & Applications"

Laura Furst and Corey R. J. Stephenson, In Carbon-carbon Bond Formations via Cross-Dehydrogenative-Coupling of C-H Bonds; Li, C.-J., Ed.; Royal Society of Chemistry.

John D. Nguyen, Bryan S. Matsuura and Corey R. J. Stephenson, J. Am. Chem. Soc. 2014, 136, 1218.

Leanne J. Sebren, James J. Devery, III and Corey R. J. Stephenson, ACS Catalysis 2014, 4, 703. PMCID: PMC3935257.

Giulia Bergonzini, Corinna S. Schindler, Carl-Johan Wallentin, Eric N. Jacobsen and Corey R. J. Stephenson Chem. Sci. 2014, 5, 112. PMCID: PMC3842187.

51) RUTHENIUM(II), TRIS(1,10-PHENANTHROLINE-KN1,KN10)-DICHLORIDE.

Joel W. Beatty and Corey R. J. Stephenson, eEROS In Press

2013 PUBLICATIONS

 

Corey R. J. Stephenson, Armido Studer and Dennis P. Curran Beil. J. Org. Chem. 2013, 9, 2778.

Pieter H. Bos, Mitchell T. Antalek, John A. Porco, Jr., and Corey R. J. Stephenson, J. Am. Chem. Soc. 2013, 135, 17978. PMCID: PMC3964885

John D. Nguyen, Barbara Reiss, Chunhui Dai and Corey R. J. Stephenson, Chem. Commun. 2013, 49, 4352. ChemComm Emerging Investigators Issue 2013

2012 PUBLICATIONS

 

John D. Nguyen, Erica M. D'Amato, Jagan M. R. Narayanam and Corey R. J. Stephenson, Nature Chem. 2012, 4, 854

Carl-Johan Wallentin, John D. Nguyen and Corey R. J. Stephenson, Chimia, 201266, 394. Special issue for the 11th International Symposium on Organic Free Radicals, Berne, Switzerland

Chunhui Dai, Bo Liang and Corey R. J. Stephenson, Beilstein J. Org. Chem. 2012, 8, 986 Special issue on chemical diversity.

Carl-Johan Wallentin, John D. Nguyen, Peter Finkbeiner and Corey R. J. Stephenson, J. Am. Chem. Soc. 2012, 134, 8875. This paper was one of the most accessed articles in May/June.

Marlena D. Konieczynska, Chunhui Dai and Corey R. J. Stephenson, Org. Biomol. Chem. 2012, 10, 4509. Invited contribution to a special web themed issue on organocatalysis. This paper was selected as a Hot article by the editors.

Chunhui Dai, Francesco Meschini, Jagan M.R. Narayanam and Corey R. J. Stephenson, J. Org. Chem. 2012, 77, 4425. This note was one of the most accessed articles in April.

Joseph W. Tucker, Yuan Zhang, Timothy F. Jamison and Corey R. J. Stephenson, Angew. Chem., Int. Ed. 2012, 51, 4144. This article was selected by the editors as a Hot Paper.

Joseph W. Tucker and Corey R. J. Stephenson, J. Org. Chem. 2012, 77, 1617. This synopsis was one of the most accessed articles in January and in the past 12 months.

David B. Freeman, Laura Furst, Allison G. Condie and Corey R. J. Stephenson, Org. Lett. 2012, 14, 94. This paper was one of the most accessed articles in December.

2011 PUBLICATIONS

 

Bryan S. Matsuura, Allison G. Condie, Ian A. McBee, Ryan C. Buff, Gregory J. Karahalis and Corey R. J. Stephenson, Org. Lett. 2011, 13, 6320.

Joseph W. Tucker and Corey R. J. Stephenson, Org. Lett. 2011, 13, 5468. PMID: 21939250

Laura Furst and Corey R. J. Stephenson, eEROS In press.

Laura Furst and Corey R. J. Stephenson, News and Views in Nat. Chem. Bio. 2011, 7, 582.

Laura Furst, Jagan M. R. Narayanam and Corey R. J. Stephenson, Angew. Chem., Int. Ed. 2011, 50, 9655. This paper was highlighted in Chemistry World and Synfacts and was selected as a Very Important Article by the editors. PMID: 21751318

Joseph W. Tucker, Jagan M. R. Narayanam, Pinkey S. Shah and Corey R. J. Stephenson, Chem. Commun. 2011, 47, 5040. PMID: 21431223

John D. Nguyen, Joseph W. Tucker, Marlena D. Konieczynska and Corey R. J. Stephenson, J. Am. Chem. Soc. 2011, 133, 4160. PMID: 21381734

Chunhui Dai, Jagan M. R. Narayanam and Corey R. J. Stephenson, Nature Chem. 20113, 140. This paper was highlighted in Chemistry World and TCE today and featured as a SynStory in SynForm. PMID: 21258387

Jagan M. R. Narayanam and Corey R. J. Stephenson, Chem. Soc. Rev. 2011, 40, 102. Invited Review PMID: 20532341

2010 PUBLICATIONS

 

Chunhui Dai and Corey R. J. Stephenson, Org. Lett. 2010, 12, 3453. This paper was one of the most accessed articles in July and in 2010. PMID: 20597471

Laura Furst, Bryan S. Matsuura, Jagan M. R. Narayanam, Joseph W. Tucker and Corey R. J. Stephenson, Org. Lett. 2010, 12, 3104. PMID: 20518528

Joseph W. Tucker, John D. Nguyen, Jagan M. R. Narayanam, Scott W. Krabbe and Corey R. J. Stephenson, Chem. Commun. 2010, 46, 4985. PMID: 20512181

Allison G. Condie, Jose-Carlos González-Gómez and Corey R. J. Stephenson, J. Am. Chem. Soc. 2010, 132, 1464. PMID: 20070079

Bo Liang, Srinivas Kalidindi, John A. Porco Jr. and Corey R. J. Stephenson, Org. Lett. 2010, 12, 572. PMID: 20050598

Joseph W. Tucker, Jagan M. R. Narayanam, Scott W. Krabbe and Corey R. J. Stephenson, Org. Lett. 2010, 12, 368. PMID: 20014770

2009 PUBLICATIONS

 

Jagan M. R. Narayanam, Joseph W. Tucker and Corey R. J. Stephenson, J. Am. Chem. Soc. 2009, 131, 8756. This paper was highlighted in C&E News and Angewandte Chemie and was one of the most read articles in June. PMID: 19552447

Professor Corey Stephenson
Willard Henry Dow Laboratory
University of Michigan
930 N University Ave
Ann Arbor, 48109

©2017 by Corey R. J. Stephenson. All Rights Reserved